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2 OMIM references -
3 associated genes
18 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
22 signs/symptoms

WAGR syndrome

ADULT syndrome

BDNF	(UniProt - OMIM)		TP63	(UniProt - OMIM)
PAX6	(UniProt - OMIM)
WT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	WT1	(0.55)	TP63

Citations in the biomedical literature:

WAGR syndrome		ADULT syndrome
	Synonym(s): - Deletion 11p13 - Monosomy 11p13 - Wilms tumor - aniridia - genitourinary anomalies - intellectual deficit		Synonym(s): - Acro-dermato-ungual-lacrimal-tooth syndrome - Pigment anomaly - ectrodactyly - hypodontia

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare eye disease - Rare genetic disease - Rare gynecologic or obstetric disease - Rare oncologic disease - Rare renal disease - Rare urogenital disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare odontologic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - 2 MeSH references: C538295 / D017624		External references: 1 OMIM reference - 1 MeSH reference: C538052

WAGR syndrome		ADULT syndrome
	Very frequent - Aniridia / iris hypoplasia - Intellectual deficit / mental / psychomotor retardation / learning disability Frequent - Anomalies of ear and hearing - Cataract / lens opacification - Hypospadias / epispadias / bent penis - Microcephaly - Micrognathia / retrognathia / micrognathism / retrognathism - Nystagmus - Protruding lips - Ptosis - Short stature / dwarfism / nanism - Undescended / ectopic testes / cryptorchidia / unfixed testes - Visual loss / blindness / amblyopia Occasional - Ambiguous genitalia - Generalized obesity - Glaucoma - Inguinal / inguinoscrotal / crural hernia - Scoliosis		Very frequent - Anomalies of eyelids, eyelashes and lacrimal system - Anomalies of teeth and dentition - Chronic skin infection / ulcerations / ulcers / cancrum - Dry / squaly skin / exfoliation - Dysplastic / thick / grooved fingernails - Dysplastic / thick / grooved toenails - Excessive freckling - Fine hair - Nails anomalies - Oligodactyly / ectrodactyly of toes - Pigmented naevi / naevus pigmentosus / lentigo - Syndactyly of fingers / interdigital palm - Syndactyly of toes - Thin skin Frequent - Alopecia - Breast tissue / mammary gland absence / aplasia - Hypoplastic / absent nipples - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness - Tooth shape anomaly Occasional - Broad nose / nasal bridge - Face / facial anomalies - High nasal bridge